Research in my lab is  focused on orthopedic immunology, primarily on mechanisms of synovial inflammation, with emphasis on endogenous mechanisms of inflammation resolution. With over a decade studying the key drivers of synovial inflammation resolution, macrophages, we use in vivo and highly translational in vitro models with a variety of 'omics technologies and have identified key mediators of inflammation resolution being investigated as pro-resolving therapeutics. Our studies are centered on horses, both as a patient population and a translational model. 

A second branch of my lab is focused on catastrophic musculoskeletal injuries in racehorses and their relationship with the suspensory apparatus biomechanics and injuries.  

 

 

Scholars@UK

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Synovial Fluid Biomarker Profile After Intra-Articular Administration of Neosaxitoxin in Horses: A Feasibility Study

Dörner, C., Lagos, N., Oyaneder, L., Menarim, B. C. & Ramírez-Toloza, G., Aug 2025, In: Animals. 15, 16, 2453.

Research output: Contribution to journalArticlepeer-review

Subclinical ketosis in postpartum dairy cows alters the adipose tissue immunological profile in a depot-specific manner

Michelotti, T. C., Menarim, B. C., Tegeler, A. P., Fiallo Diez, J. F., Machado, V. S., Jones-Hall, Y., Benitez, O. J., Loux, S. C. & Strieder-Barboza, C., 2025, In: Frontiers in Immunology. 16, 1578669.

Research output: Contribution to journalArticlepeer-review

Transcriptomic and histochemical analysis reveal the complex regulatory networks in equine chorioallantois during spontaneous term labor

Ali, H. E. S., Scoggin, K., Murase, H., Norris, J., Menarim, B., Dini, P. & Ball, B., Nov 1 2022, In: Biology of Reproduction. 107, 5, p. 1296-1310 15 p.

Research output: Contribution to journalArticlepeer-review

Urinary Bladder Matrix Does Not Improve Tenogenesis in an In Vitro Equine Model

Khatibzadeh, S. M., Menarim, B. C., Nichols, A. E. C., Werre, S. R. & Dahlgren, L. A., Aug 1 2019, In: Journal of Orthopaedic Research. 37, 8, p. 1848-1859 12 p.

Research output: Contribution to journalArticlepeer-review

Use of hypometabolic TRIS extenders and high cooling rate refrigeration for cryopreservation of stallion sperm: Presence and sensitivity of 5' AMP-activated protein kinase (AMPK)

Córdova, A., Strobel, P., Vallejo, A., Valenzuela, P., Ulloa, O., Burgos, R. A., Menarim, B., Rodríguez-Gil, J. E., Ratto, M. & Ramírez-Reveco, A., 2014, In: Cryobiology. 69, 3, p. 473-481 9 p.

Research output: Contribution to journalArticlepeer-review

Growth factor modulation of equine trophoblast mitosis and prostaglandin gene expression

Bonometti, S., Menarim, B. C., Reinholt, B. M., Ealy, A. D. & Johnson, S. E., Feb 1 2019, In: Journal of Animal Science. 97, 2, p. 865-873 9 p.

Research output: Contribution to journalArticlepeer-review

Intra-articular bone marrow mononuclear cell therapy improves lameness from naturally occurring equine osteoarthritis

Everett, J. B., Menarim, B. C., Barrett, S. H., Bogers, S. H., Byron, C. R., Pleasant, R. S., Werre, S. R. & Dahlgren, L. A., 2023, In: Frontiers in Veterinary Science. 10, 1256284.

Research output: Contribution to journalArticlepeer-review

Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows

Michelotti, T. C., Kisby, B. R., Flores, L. S., Tegeler, A. P., Fokar, M., Crasto, C., Menarim, B. C., Loux, S. C. & Strieder-Barboza, C., Oct 14 2022, In: Frontiers in Cell and Developmental Biology. 10, 1025240.

Research output: Contribution to journalArticlepeer-review

Macrophage Activation in the Synovium of Healthy and Osteoarthritic Equine Joints

Menarim, B. C., Gillis, K. H., Oliver, A., Ngo, Y., Werre, S. R., Barrett, S. H., Rodgerson, D. H. & Dahlgren, L. A., Nov 26 2020, In: Frontiers in Veterinary Science. 7, 568756.

Research output: Contribution to journalArticlepeer-review

Main musculoskeletal injuries associated with lameness in Chilean Rodeo horses

Mora-Carreno, M., Briones, R., Galecio, J. S., Parra, D., Rosenfeld, C., Schmeisser, A. & Menarim, B., 2014, In: Archivos de Medicina Veterinaria. 46, 3, p. 419-424 6 p.

Research output: Contribution to journalArticlepeer-review

Autologous bone marrow mononuclear cells modulate joint homeostasis in an equine in vivo model of synovitis

Menarim, B. C., Gillis, K. H., Oliver, A., Mason, C., Ngo, Y., Werre, S. R., Barrett, S. H., Luo, X., Byron, C. R. & Dahlgren, L. A., Dec 2019, In: FASEB Journal. 33, 12, p. 14337-14353 17 p.

Research output: Contribution to journalArticlepeer-review

Urinary bladder matrix does not improve tenogenesis in an in vitro equine model

Khatibzadeh, S. M., Menarim, B. C., Nichols, A. E. C., Were, S. R. & Dahlgren, L. A., 2019, In: Journal of Orthopaedic Research. 2019

Research output: Contribution to journalArticlepeer-review

Racing and sales performance in Thoroughbred yearlings after carpal osteochondral fragment removal

Debald, D. C., Stanton, V. L., Sandow, C. B., Rodgerson, D. H., Spirito, M. A., Hunt, R. J. & Menarim, B. C., 2025, (Accepted/In press) In: Equine Veterinary Journal.

Research output: Contribution to journalArticlepeer-review

How to obtain and isolate equine sternal bone marrow mononuclear cells with limited resources

Corrêa, F., Borlone, C., Wittwer, F., Bustamante, H., Müller, A., Ramírez, A. & Menarim, B., 2014, In: Archivos de Medicina Veterinaria. 46, 3, p. 471-476 6 p.

Research output: Contribution to journalArticlepeer-review

Radiographic Abnormalities in Barrel Racing Horses with Lameness Referable to the Metacarpophalangeal Joint

Menarim, B. C., Vasconcelos Machado, V. M., Cisneros Alvarez, L. E., Carneiro, R., Busch, L. & Vulcano, L. C., Apr 2012, In: Journal of Equine Veterinary Science. 32, 4, p. 216-221 6 p.

Research output: Contribution to journalArticlepeer-review

Transcriptional and Histochemical Signatures of Bone Marrow Mononuclear Cell-Mediated Resolution of Synovitis

Menarim, B. C., El-Sheikh Ali, H., Loux, S. C., Scoggin, K. E., Kalbfleisch, T. S., MacLeod, J. N. & Dahlgren, L. A., Dec 8 2021, In: Frontiers in Immunology. 12, 734322.

Research output: Contribution to journalArticlepeer-review

Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair

Menarim, B. C., MacLeod, J. N. & Dahlgren, L. A., 2021, In: World Journal of Stem Cells. 13, 7, p. 825-840 16 p.

Research output: Contribution to journalArticlepeer-review

Inflamed synovial fluid induces a homeostatic response in bone marrow mononuclear cells in vitro: Implications for joint therapy

Menarim, B. C., Gillis, K. H., Oliver, A., Mason, C., Werre, S. R., Luo, X., Byron, C. R., Kalbfleisch, T. S., MacLeod, J. N. & Dahlgren, L. A., Mar 1 2020, In: FASEB Journal. 34, 3, p. 4430-4444 15 p.

Research output: Contribution to journalArticlepeer-review

Education

  • 2004 - DVM, Midwest State University, Parana - Brazil.
  • 2007 - Large Animal Surgery Residency, Sao Paulo State University, Sao Paulo - Brazil.
  • 2009 - MS, Veterinary Radiology, Sao Paulo State University, Sao Paulo - Brazil.
  • 2019 - PhD, Biomedical Sciences, Virginia Maryland College of Veterinary Medicine - Blacksburg, VA
  • 2023 - Postdoc, Rheumatology, Gluck Equine Research Center - Lexington, Kentucky

Associated Departments

Veterinary Science