Scholars@UK
Analysis of IgG responses to Sarcocystis neurona in horses with equine protozoal myeloencephalitis (EPM) suggests a Th1-biased immune response
Angwin, C. J., de Assis Rocha, I., Reed, S. M., Morrow, J. K., Graves, A. & Howe, D. K., Nov 2025, In: Veterinary Immunology and Immunopathology. 289, 111009.Research output: Contribution to journal › Article › peer-review
Prevalence of anti-N. caninum and anti-N. hughesi antibodies in horses and associated risk factors in two selected equine zones of Punjab, Pakistan
Talib, M. T., Nasir, A., Kashif, M., Rahman, A., Rehman, A. U., Akbar, H., Nadeem, A., Howe, D. K. & Azam, M. N., Feb 2025, In: Veterinary Parasitology: Regional Studies and Reports. 58, 101211.Research output: Contribution to journal › Article › peer-review
Characterization of SnROP9, a rhoptry protein homologue of Sarcocystis neurona that is expressed in lifecycle stages lacking rhoptry organelles
Jegatheesan, A., Micciche, M., Ngo, J., Bradley, P. J., Howe, D. K. & Dangoudoubiyam, S., May 2025, In: International Journal for Parasitology. 55, 6, p. 327-337 11 p.Research output: Contribution to journal › Article › peer-review
Tropical Density Estimation of Phylogenetic Trees
Yoshida, R., Barnhill, D., Miura, K. & Howe, D., Nov 2024, In: IEEE/ACM Transactions on Computational Biology and Bioinformatics. 21, 6, p. 1855-1863 9 p.Research output: Contribution to journal › Article › peer-review
Temporal gene expression during asexual development of the apicomplexan Sarcocystis neurona
Dangoudoubiyam, S., Norris, J. K., Namasivayam, S., de Paula Baptista, R., do Nascimento, N. C., Camp, J., Schardl, C. L., Kissinger, J. C. & Howe, D. K., Jun 2024, In: mSphere. 9, 6Research output: Contribution to journal › Article › peer-review
Systemic Caryospora-like coccidiosis in a clutch of hatchling red-eared slider turtles (Trachemys scripta elegans)
Falconnier, N., Warshaw, M., Wellehan, J. F. X., Childress, A. L., Howe, D. K., Taylor, H., Langohr, I. M., Ard, M. B., Paulsen, D. B., Sasaki, E., Mitchell, M. S. & Carossino, M., Jan 2024, In: Veterinary Pathology. 61, 1, p. 95-108 14 p.Research output: Contribution to journal › Article › peer-review
Equine Protozoal Myeloencephalitis
MacKay, R. J. & Howe, D. K., Aug 2022, In: Veterinary Clinics of North America - Equine Practice. 38, 2, p. 249-268 20 p.Research output: Contribution to journal › Review article › peer-review
Transcriptional dynamics in the protozoan parasite Sarcocystis neurona and mammalian host cells after treatment with a specific inhibitor of apicomplexan mRNA polyadenylation
Hunt, A. G., Howe, D. K., Brown, A. & Yeargan, M., Oct 2021, In: PLoS ONE. 16, 10 October, e0259109.Research output: Contribution to journal › Article › peer-review
Pathologic and immunohistochemical findings in an outbreak of systemic toxoplasmosis in a mob of red kangaroos
Carossino, M., Bauer, R., Mitchell, M. A., Cummings, C. O., Stöhr, A. C., Wakamatsu, N., Harper, K., Langohr, I. M., Schultz, K., Mitchell, M. S., Howe, D. K. & Balasuriya, U. B. R., May 2021, In: Journal of Veterinary Diagnostic Investigation. 33, 3, p. 554-565 12 p.Research output: Contribution to journal › Article › peer-review
Expression of Toxoplasma gondii genes in the closely-related apicomplexan parasite Neospora caninum
Howe, D. K., Mercier, C., Messina, M. & Sibley, L. D., May 1997, In: Molecular and Biochemical Parasitology. 86, 1, p. 29-36 8 p.Research output: Contribution to journal › Article › peer-review
Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy
Ojo, K. K., Dangoudoubiyam, S., Verma, S. K., Scheele, S., DeRocher, A. E., Yeargan, M., Choi, R., Smith, T. R., Rivas, K. L., Hulverson, M. A., Barrett, L. K., Fan, E., Maly, D. J., Parsons, M., Dubey, J. P., Howe, D. K. & Van Voorhis, W. C., Dec 1 2016, In: International Journal for Parasitology. 46, 13-14, p. 871-880 10 p.Research output: Contribution to journal › Article › peer-review
Seroepidemiology of Sarcocystis neurona and Neospora hughesi infections in domestic donkeys (Equus asinus) in Durango, Mexico
Alvarado-Esquivel, C., Howe, D. K., Yeargan, M. R., Alvarado-Esquivel, D., Alfredo Zamarripa-Barboza, J. & Dubey, J. P., 2017, In: Parasite. 24, 2, 24.Research output: Contribution to journal › Article › peer-review
Neospora caninum antibodies detected in Midwestern white-tailed deer (Odocoileus virginianus) by Western blot and ELISA
Anderson, T., DeJardin, A., Howe, D. K., Dubey, J. P. & Michalski, M. L., Apr 10 2007, In: Veterinary Parasitology. 145, 1-2, p. 152-155 4 p.Research output: Contribution to journal › Article › peer-review
A new trivalent SnSAG surface antigen chimera for efficient detection of antibodies against Sarcocystis neurona and diagnosis of equine protozoal myeloencephalitis
Yeargan, M., de Assis Rocha, I., Morrow, J., Graves, A., Reed, S. M. & Howe, D. K., May 6 2015, In: Journal of Veterinary Diagnostic Investigation. 27, 3, p. 377-381 5 p.Research output: Contribution to journal › Article › peer-review
The apicomplexan pathogen Neospora caninum inhibits host cell apoptosis in the absence of discernible NF-κB activation
Herman, R. K., Molestina, R. E., Sinai, A. P. & Howe, D. K., Sep 2007, In: Infection and Immunity. 75, 9, p. 4255-4262 8 p.Research output: Contribution to journal › Article › peer-review
Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondii
Yap, G. S., Scharton-Kersten, T., Ferguson, D. J. P., Howe, D., Suzuki, Y. & Sher, A., 1998, In: Infection and Immunity. 66, 9, p. 4382-4388 7 p.Research output: Contribution to journal › Article › peer-review
Differential roles for inner membrane complex proteins across Toxoplasma gondii and Sarcocystis neurona development
Dubey, R., Harrison, B., Dangoudoubiyam, S., Bandini, G., Cheng, K., Kosber, A., Agop-Nersesian, C., Howe, D. K., Samuelson, J., Ferguson, D. J. P. & Gubbels, M. J., Sep 1 2017, In: mSphere. 2, 5, e00409-17.Research output: Contribution to journal › Article › peer-review
Investigation of SnSPR1, a novel and abundant surface protein of Sarcocystis neurona merozoites
Zhang, D. & Howe, D. K., Apr 15 2008, In: Veterinary Parasitology. 152, 3-4, p. 210-219 10 p.Research output: Contribution to journal › Article › peer-review
Characterization of the oregon isolate of Neospora hughesi from a horse
Dubey, J. P., Liddell, S., Mattson, D., Speer, C. A., Howe, D. K. & Jenkins, M. C., 2001, In: Journal of Parasitology. 87, 2, p. 345-353 9 p.Research output: Contribution to journal › Article › peer-review
Accurate antemortem diagnosis of equine protozoal myeloencephalitis (EPM) based on detecting intrathecal antibodies against sarcocystis neurona using the SnSAG2 and SnSAG4/3 ELISAs
Reed, S. M., Howe, D. K., Morrow, J. K., Graves, A., Yeargan, M. R., Johnson, A. L., Mackay, R. J., Furr, M., Saville, W. J. A. & Williams, N. M., Sep 2013, In: Journal of Veterinary Internal Medicine. 27, 5, p. 1193-1200 8 p.Research output: Contribution to journal › Article › peer-review
Investigation of the Immunopathogenesis of Equine Protozoal Myeloencephalitis (EPM)
de Assis Rocha, I. (PI) & Howe, D. (CoI)
5/1/24 → 4/30/26
Project: Research project
Bumped Kinase Inhibitor for Toxoplasmosis and and Sarcocystosis
Howe, D. (PI) & Page, A. (CoPI)
6/1/20 → 5/31/26
Project: Research project
Evaluation of Sarcocystis Neurona Antigens for Development of Subunit Vaccines Against Equine Protozoal Myeloencephalitis
Howe, D. (PI) & Horohov, D. (CoI)
4/1/01 → 3/31/07
Project: Research project
Genome Sequence for the Apicomplexan Sarcocystis Neurona
Howe, D. (PI) & Schardl, C. (CoI)
Cooperative State Research Education and Extension
9/1/09 → 8/31/13
Project: Research project
Advanced Genetic Technologies
Schardl, C. (PI) & Howe, D. (CoI)
Cooperative State Research Education and Extension
9/1/08 → 8/31/11
Project: Research project
KSEF KCF: Novel Therapeutic Approaches to Treatment of Parasitic Disease and Related Clinical Conditions
Tobin, T. (PI), Howe, D. (CoI) & Pauly, J. (CoI)
KY Science and Technology Co Inc
4/1/07 → 12/31/10
Project: Research project
Advanced Genetic Technologies
Schardl, C. (PI), Downie, A. (CoI), Ghabrial, S. (CoI), Howe, D. (CoI), Matthews, J. (CoI), McLeod, K. (CoI) & Timoney, J. (CoI)
Cooperative State Research Education and Extension
7/1/03 → 6/30/05
Project: Research project
Enhancing Genetic Analysis and Sequencing Facility
Schardl, C. (PI), Gan, S. (CoI), Howe, D. (CoI), Nagy, P. (CoI), Perry, S. (CoI) & Webb, B. (CoI)
1/1/02 → 12/31/04
Project: Research project
Identification and Characterization of Immunodominant Antigens from Sarcocystis neurona, the Primary Cause of EPM
Howe, D. (PI)
1/1/01 → 12/31/05
Project: Research project
Associated Departments